Published Scientific articles

Research Articles

  1. Patani, R., Hollins, A.J., Wishart, T.M., Puddifoot, C.A., Alvarez, S., de Lera, A.R., Wyllie, D.J., Compston, D.A., Pedersen, R.A., Gillingwater, T.H., Hardingham, G.E., Allen, N.D., Chandran, S. (2011) “Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state”. Nature Communications. 2:214.
  2. Benter, I.F., Benboubetra, M., Hollins, A.J., Yousif, M.H., Canatan, H., Akhtar, S. (2009) “Early inhibition of EGFR signaling prevents diabetes-induced up-regulation of multiple gene pathways in the mesenteric vasculature”. Vascular Pharmacology 51 (4), 236-245.
  3. Davies V.J., Powell K.A., White K.E., Yip W., Hogan V., Hollins A.J., Davies J.R., Piechota M., Brownstein D.G., Moat S.J., Nichols P.P., Wride M.A., Boulton M.E., Votruba M. (2008 ) “A missense mutation in the murine Opa3 gene models human Costeff syndrome”. Brain 131 (2), 368-380.
  4. Hollins A.J., Omidi Y., Benter I.F., Akhtar S. (2007) “Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity”. The Journal of Drug Targeting 15 (1), 83-88.
  5. Davies V.J., Hollins A.J., Piechota M.J., Yip W., Davies J.R., White K.E., Nicols P.P., Boulton M.E., Votruba M. (2007) “Opa1 deficiency in a mouse model of Autosomal Dominant Optic Atrophy impairs mitochondrial morphology, optic nerve structure and visual function”. Human Molecular Genetics 16(11), 1307-1318.
  6. Barar J., Campbell L., Hollins A.J., Thomas N.P.B., Smith M.W., Morris C.J., Gumbleton M. (2007) “Cell selective glucocorticoid induction of caveolin-1 and caveolae in differentiating pulmonary alveolar epithelial cell cultures”. Biochemical and Biophysical Research Communications 359(2), 360-366.
  7. Omidi Y., Hollins A.J., Drayton R.M., Akhtar S. (2005) “Polypropylenimine dendrimer-induced gene expression changes: The effect of complexation with DNA, dendrimer generation and cell type”. The Journal of Drug Targeting 13 (7), 431-443.
  8. Benter I.F., Yousif M.H., Hollins A.J., Griffiths S.M., Akhtar S. (2005) “Diabetes-induced renal vascular dysfunction is normalized by inhibition of epidermal growth factor receptor tyrosine kinase”. Journal of Vascular Research 42 (4), 284-291.
  9. Hollins A.J., Benboubetra M., Omidi Y., Zinselmeyer B.H., Schatzlein A.G., Uchegbu I.F., Akhtar S. (2004) “Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor”. Pharmaceutical Research 21 (3), 458-466.
  10. Hussain M., Shchepinov M., Sohail M., Benter I.F., Hollins A.J., Southern E.M., Akhtar S. (2004) “A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides”. Journal of Control Release 99 (1), 139-155.
  11. Omidi Y., Hollins A.J., Benboubetra M., Drayton R., Benter I.F., Akhtar S. (2003) “Toxicogenomics of non-viral vectors for gene therapy: A microarray study of Lipofectin- and Oligofectamine-induced gene expression changes in human epithelial cells”. The Journal of Drug Targeting 11(6), 311-323.
  12. Beale G., Hollins A.J., Benboubetra M., Sohail M., Benter I., Southern E.M., Akhtar S. (2003) “Gene Silencing Nucleic Acids Designed by Scanning Arrays: Anti-EGFR Activity of siRNA, Ribozyme and DNA Enzymes Targeting a Single Hybridization-accessible Region using the Same Delivery System”. The Journal of Drug Targeting 11 (7), 449-456.
  13. Fuchs S.*, Hollins A.J.*, Laue M., Schaefer U.F., Roemer K., Gumbleton M., Lehr C.M. (2003) “Differentiation of human alveolar epithelial cells in primary culture. Morphological characterization and synthesis of caveolin-1 and Sp-C”. Cell Tissue Research 311, 31-45. (* First two authors contributed equally).
  14. Campbell L., Abulrob A.N., Kandalaft L.E., Plummer S., Hollins A.J., Gibbs A., Gumbleton M. (2003) “Constitutive expression of P-glycoprotein in normal lung alveolar epithelium and functionality in primary alveolar epithelial cultures”. Journal of Pharmacological and Experimental Therapeutics 304 (1), 441-452.
  15. Hollins A.J., Campbell L., Gumbleton M., Evans D.J.R. (2002) “Caveolin expression during chondrogenesis in the avian limb”. Developmental Dynamics 225, 205-211.
  16. Campbell L., Hollins A.J., Al-Eid A., Newman G.R., von Ruhland C., Gumbleton M. (1999) “Caveolin-1 expression and caveolae biogenesis during cell transdifferentiation in lung alveolar epithelial primary cultures”. Biochemical and Biophysical Research Communications 262, 744-751.

Review Articles

  1. Gilmore I.R., Fox S.P., Hollins A.J., Akhtar S. (2006) “Delivery strategies for siRNA-mediated gene silencing”. Current Drug Delivery 3 (2), 147-155.
  2. Gilmore I.R., Fox S.P., Hollins A.J., Sohail M., Akhtar S. (2004) “The design and exogenous delivery of siRNA for post-transcriptional gene silencing”. Journal of Drug Targeting 12 (6), 315-340.
  3. Gumbleton, M, Hollins A.J., Omidi, Y., Campbell, L., Taylor, G. (2003) “Targetting caveolae for vesicular drug transport”. Journal of Controlled Release 87 (1-3), 139-151.

Book Chapters

  1. Hollins A.J., Fox S.P., Akhtar S. (2004) Chapter 9. “Exogenous siRNA delivery: protocols for optimising delivery to cells, in Gene Silencing by RNA Interference: Technology and Applications” M Sohail (Ed) CRC Press, Boca Raton, USA. ISBN-10: 0849321417